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Possible Human Papillomavirus Etiology

Allan L. Abramson, MD; Janet Brandsma, PhD; Bettie Steinberg, PhD; Barbara Winkler, MD

Arch Otolaryngol. 1985;111(11):709-715.

Abstract
• Verrucous carcinoma of the larynx is a distinct and uncommon variant of well-differentiated squamous cell carcinoma. By DNA hybridization techniques, we clearly demonstrated human papillomavirus HPV-16–related) sequences in five patients with this neoplasm. In addition, HPV-16–related sequences were found in adjacent normal tissues. The DNAs from squamous cell carcinomas of the larynx were negative when hybridized to HPV-6, -11, or -16. Postirradiation anaplastic transformation of verrucous carcinoma has been described. We believe that radiotherapy should not be given unless the potential consequences are fully explained because of its potential to activate or alter HPV-16–related sequences.

(Arch Otolaryngol 1985;111:709-715)

Author Affiliations
From the Departments of Otolaryngology and Communicative Disorders (Drs Abramson, Brandsma, and Steinberg) and Pathology (Dr Winkler), Long Island Jewish Medical Center, New Hyde Park, NY.

Footnotes
Accepted for publication July 5, 1985.

Read before the American Society for Head and Neck Surgery, Dorado Beach, Puerto Rico, May 8, 1985.

Reprint requests to Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042 (Dr Abramson).

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