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A Hazard in Head and Neck Chemotherapy

Peter A. Wallenborn, III, MD; Duncan S. Postma, MD

Arch Otolaryngol. 1984;110(9):614-617.

Abstract
• The enhanced effects of chemotherapy on previously irradiated tissue have been well demonstrated. When chemotherapy is given some time after irradiation and elicits a tissue reaction in the radiation field, the reaction is termed radiation recall. We review known interactions between chemotherapy and radiotherapy and report, to our knowledge, the first case of a supraglottitis radiation recall reaction. Familiarity with this phenomenon and potential complications of chemotherapy following head and neck irradiation may expedite early diagnosis and appropriate lifesaving treatment.

(Arch Otolaryngol 1984;110:614-617)

Author Affiliations
From the Division of Otolaryngology, University of North Carolina School of Medicine, Chapel Hill.

Footnotes
Accepted for publication Dec 31, 1983.

Reprint requests to Division of Otolaryngology, 610 Burnett-Womack Bldg, Room 229-H, University of North Carolina, Chapel Hill, NC 27514 (Dr Postma).

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