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William J. Doyle, PhD; Roger Friedman, MD; Philip Fireman, MD; Charles D. Bluestone, MD

Arch Otolaryngol. 1984;110(8):508-511.

Abstract
• To test if allergic rhinitis is associated with abnormal eustachian tube function (ET), juvenile rhesus monkeys were passively sensitized with serum samples from patients allergic to timothy grass or ragweed pollen. Tympanostomy tubes were inserted for direct measurement of ET function by inflation-deflation and forced-response testing before and after provocative intranasal challenge. Intranasal challenge with pollen (antigen) resulted in rhinorrhea and nasal obstruction. Slight increases in passive ET function values and significantly impaired active ET function were observed after antigen challenge. No changes in nasal airway patency or active ET function resulted from control nonantigen pollen challenges. These data complement our studies in man and support the use of this model to evaluate the relationships among allergic rhinitis, ET function and middle ear disease.

(Arch Otolaryngol 1984;110:508-511)

Author Affiliations
From the Departments of Otolaryngology (Drs Doyle and Bluestone) and Allergy and Immunology (Drs Friedman and Fireman), Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication April 25, 1984.

Reprint requests to the Department of Otolaryngology, Children's Hospital of Pittsburgh, 125 DeSoto St, Pittsburgh, PA 15213 (Dr Doyle).

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