You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 110 No. 5, May 1984 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Characterization of antibody-forming cells adjacent to laryngeal carcinoma

J. R. Danielson and W. A. Franklin

Plasma cells are often found in the stroma adjacent to squamous carcinoma of the larynx, although the class of immunoglobulin produced by these cells is unknown. Using an immunofluorescence technique with counterstaining by homidium bromide, we determined the proportion of plasmacytic cells producing IgG, IgA, IgM, IgD, IgE, kappa-light chain, and lambda-light chain immunoglobulins adjacent to tumor. IgG was found in 80% to 90% of the plasma cells at primary and metastatic sites. IgA and IgM were found in lesser percentages. IgA was often found in small clusters. IgE was found in rare isolated cells adjacent to tumor, but no IgD-containing cells were detected. Approximately equal numbers of kappa- and lambda-bearing cells were found. These findings indicate an IgG humoral immune response commonly occurs adjacent to squamous carcinoma of the larynx.





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1984 American Medical Association. All Rights Reserved.