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Electronystagmographic Findings in Long-term Low-Dose Quinine IngestionA Preliminary Report
COL Joan T. Zajtchuk, MC;
CPT Radu Mihail, MC;
MAJ John S. Jewell, MSC;
CAPT Michael J. Dunne, MC;
Susan G. Chadwick, MA
Arch Otolaryngol. 1984;110(12):788-791.
Abstract
• Seventeen subjects were used in this study to measure the long-term effects of low-dose quinine ingestion as correlated with electronystagmographic (ENG) findings in humans. Four subjects served as controls, nine subjects (low-dose group) drank 52.5 mg of quinine per day, and four subjects (high-dose group) drank 105 mg of quinine per day in commercially prepared tonic water. Only the high-dose group showed transient positional testing abnormalities on ENG. In our experiment, the high-dose group ingested one third of the recommended Food and Drug Administration adult daily oral dose of quinine.
(Arch Otolaryngol 1984;110:788-791)
Author Affiliations
USA; USA; USA
From the Otolaryngology—Head and Neck Surgery Section (Drs Zajtchuk and Mihail), the Audiology and Speech Center (Ms Chadwick), Department of Surgery, Walter Reed Army Medical Center, and the Divisions of Toxicology (MAJ Jewell) and Aerospace Medicine (Dr Dunne), Armed Forces Institute of Pathology, Washington, DC.
Footnotes
Accepted for publication May 22, 1984.
The views or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Reprint requests to Otolaryngology—Head and Neck Surgery Service, Walter Reed Army Medical Center, Washington, DC 20307-5001 (Dr Zajtchuk).
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