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Atypical Carcinoid Tumor of the LarynxA Light Microscopic and Ultrastructural Study
Stacey E. Mills, MD;
Michael E. Johns, MD
Arch Otolaryngol. 1984;110(1):58-62.
Abstract
• A 68-year-old man had an 11-year history of a recurring carcinoid tumor of the larynx. In six additional examples of this uncommon neoplasm, cervical lymph node metastases were present in four patients and osseous involvement developed in another. Two patients died of their disease, one died without evidence of neoplasm, and four were living and clinically free of tumor at last follow-up. Laryngeal carcinoids are often atypical histologically and may be misdiagnosed as undifferentiated carcinoma, prompting inappropriate radiation therapy for a radiation-resistant neoplasm. Histologic features suggestive of carcinoid include a nesting or trabecular growth pattern and prominent perineural invasion. Argyrophil stains were positive in four of five cases. Ultrastructurally, these neoplasms have abundant dense core granules.
(Arch Otolaryngol 1984;110:58-62)
Author Affiliations
From the Departments of Pathology (Dr Mills) and Otolaryngology—Head and Neck Surgery (Dr Johns), University of Virginia Medical Center, Charlottesville.
Footnotes
Accepted for publication Feb 1, 1983.
Reprint requests to Department of Pathology, Box 214, University of Virginia Medical Center, Charlottesville, VA 22908 (Dr Mills).
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