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In Vitro and Preliminary Clinical Experiences

Barry Hirsch, MD; Jonas T. Johnson, MD; Bruce S. Rabin, MD, PhD; Patricia B. Thearle, RN

Arch Otolaryngol. 1983;109(5):298-301.

Abstract
• The development of malignancy is theorized to be from failure of the immunosurveillance system. Prostaglandins (PGs), synthesized by a mononuclear cell, tumor cell, or both, enhance inhibition of competent cellular immunity. Ten patients with terminal squamous cell carcinoma of the head and neck were treated with indomethacin, an inhibitor of PG synthesis. Two patients had a dramatic response; however, an in vitro assay and a derived-stimulation index did not correlate with the clinical response. A review of the literature and future directions are discussed.

(Arch Otolaryngol 1983;109:298-301)

Author Affiliations
From the Division of Otolaryngology, Georgetown University School of Medicine, Georgetown University Hospital, Washington, DC (Dr Hirsch); and the Departments of Otolaryngology (Dr Johnson and Ms Thearle) and Pathology (Dr Rabin), University of Pittsburgh School of Medicine; and the Eye and Ear Hospital, Pittsburgh; (Dr Johnson and Ms Thearle); and Presbyterian-University Hospital, Pittsburgh (Dr Rabin).

Footnotes
Accepted for publication Dec 10, 1982.

Read in part before the American Society of Head and Neck Surgeons, Palm Beach, Fla, May 6, 1981.

Reprint requests to the Medical Librarian, Eye and Ear Hospital, 230 Lothrop St, Pittsburgh, PA 15213 (Dr Johnson).

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