Food and chemical sensitivity. Clinical and immunologic correlates
J. J. McGovern Jr, J. A. Lazaroni, M. F. Hicks, J. C. Adler and P. Cleary
Six allergic patients and six normal controls were studied serologically
before and after provocative challenge with allergic substances. The
patients showed impaired modulation of the immune system prior to
challenge. The challenge blood changes in patients with adverse clinical
responses were consistent with type 1 and/or type 3 immune responses.
Normal controls showed no abnormal laboratory or clinical changes. The data
support the hypothesis that an abnormal immune reaction develops in
allergic patients who sustain an adverse clinical response to ingestion of
foods or inhalation of chemicals to which they are sensitive.
