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Clinical and Immunologic Correlates

Joseph J. McGovern, Jr, MD; Joseph A. Lazaroni, PhD; Marilyn F. Hicks, MD; John C. Adler, MS; Pauline Cleary

Arch Otolaryngol. 1983;109(5):292-297.

Abstract
• Six allergic patients and six normal controls were studied serologically before and after provocative challenge with allergic substances. The patients showed impaired modulation of the immune system prior to challenge. The challenge blood changes in patients with adverse clinical responses were consistent with type 1 and/or type 3 immune responses. Normal controls showed no abnormal laboratory or clinical changes. The data support the hypothesis that an abnormal immune reaction develops in allergic patients who sustain an adverse clinical response to ingestion of foods or inhalation of chemicals to which they are sensitive.

(Arch Otolaryngol 1983;109:292-297)

Author Affiliations
From the Clinic for Environmental Illness (Drs McGovern and Hicks, Mr Adler, and Ms Cleary), Merritt Hospital (Dr McGovern), Oakland, Calif; Lazaroni Laboratories, Daly City, Calif (Dr Lazaroni); and the Department of Nutrition, Brigham Young University, Salt Lake City (Dr McGovern).

Footnotes
Accepted for publication Aug 18, 1982.

Deceased.

Read before the Third International Food Allergy Symposium, Boston, Oct 21, 1980.

Reprint requests to 400 29th St, Oakland, CA 94609 (Dr McGovern).

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