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Report of Two Tumors With Immunohistochemical and Ultrastructural Analysis

Nour Sneige, MD; Bruce Mackay, MD, PhD; Nelson G. Ordonez, MD; John G. Batsakis, MD

Arch Otolaryngol. 1983;109(2):113-117.

Abstract
• Paraganglionic tumors of the larynx are uncommon neoplasms and their secretory products have rarely been elucidated. We saw two patients whose laryngeal paragangliomas were examined with an electron microscope and by the use of immunocytochemical techniques. Both tumors manifested positive immunoreactivity against calcitonin and vasoactive intestinal polypeptide. One of the paragangliomas was immunoreactive against carcinoembryonic antigen and pursued a biologically malignant course. Our observations suggest the coexistence of amines and hormonal polypeptides in cells of paraganglionic tumors and demonstrate the multihormonal nature of these tumors.

(Arch Otolaryngol 1983;109:113-117)

Author Affiliations
From the Department of Pathology, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston.

Footnotes
Accepted for publication July 16, 1982.

Reprint requests to the Department of Pathology, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, 6723 Bertner, Houston, TX 77030 (Dr Batsakis).

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