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Andrew Blitzer, DDS, MD; Cheng Chun Huang, PhD

Arch Otolaryngol. 1983;109(11):719-723.

Abstract
• The in vivo effect of indomethacin therapy in head and neck cancer was tested using rats (Fisher 344) with implanted epithelial palatal carcinoma. Indomethacin was then given to half of the rats in their drinking water, starting two weeks after tumor implantation. The animals were then killed at four weeks and the tumor volumes were measured. It was found that four (21%) of the 19 rats were complete responders and eight (42%) of the 19 rats were partial responders. The control group showed increased tumor growth in all animals. The experimental group also demonstrated five (26%) of the 19 regional metastases. No metastases were seen in the control group. Indomethacin seems to inhibit local tumor growth, perhaps through its effects on cellular and humoral immunity and its effects on the host-tissue stroma. It also may increase tumor spread through the regional lymphatics or hematogenously. Further animal studies need to be carried out to determine the effect on cancer on a cellular and biochemical level before using it for treatment of cancer in humans.

(Arch Otolaryngol 1983;109:719-723)

Author Affiliations
From the Department of Otolaryngology, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Accepted for publication May 11, 1983.

Read before the American Society for Head and Neck Surgery, Palm Springs, Calif, March 11, 1983.

Reprint requests to the Department of Otolaryngology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032 (Dr Blitzer).

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