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Effect of Topically Applied Antiseptics

Tetsuo Morizono, MD; Michael A. Sikora

Arch Otolaryngol. 1983;109(10):677-681.

Abstract
• The ototoxic effect of povidoneiodine antiseptics topically applied to the chinchilla round window was examined with particular emphasis on the action potential (AP) input-output function at 2 and 4 kHz. A group of chinchillas exhibited a marked elevation of AP threshold at 8 and 12 kHz, with only a slight threshold elevation at 2 and 4 kHz. A distinct decruitment (less than normal growth of response with increasing sound intensity) of the AP input-output function was, however, found at the lower frequencies. There are implications of an ototoxically induced high-frequency hearing loss on speech frequencies.

(Arch Otolaryngol 1983;109:677-681)

Author Affiliations
From the Otophysiology Research Laboratory, Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.

Footnotes
Accepted for publication April 18, 1983.

Reprint requests to Department of Otolaryngology, 2630 University Ave SE, Minneapolis, MN 55414 (Dr Morizono).

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