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Immunoglobulins in Perilymph

Goro Mogi, MD; David J. Lim, MD; Noritake Watanabe, MD

Arch Otolaryngol. 1982;108(5):270-275.

Abstract
• The immunoglobulin composition of perilymph (PL) was measured using electroimmunodiffusion, and transfer of serum antibodies to PL was studied using a passive hemagglutination test in chinchillas and guinea pigs. The mean values of IgG and albumin in PL were two to four times greater than those in CSF. In guinea pigs, IgA was found in 93% of the PL and 32% of the CSF samples, but in chinchillas only trace amounts of IgA were found in 50% of the PL and 15% of the CSF samples. No IgM was detected in PL or CSF of either species. This study suggests that a greater portion of the immunoglobulins in PL probably is derived from perilymphatic blood vessels as a filtrate and that the perilymphatic inner ear immune system is independent from that of the CSF.

(Arch Otolaryngol 1982;108:270-275)

Author Affiliations
From the Department of Otolaryngology, Otological Research Laboratories, Ohio State University College of Medicine, Columbus. Dr Mogi is now with the Oita Medical College, Oita, Japan. Dr Watanabe is now with the Oita Prefecture Hospital, Oita, Japan.

Footnotes
Accepted for publication Sept 9, 1981.

Read in part before the American Academy of Otolaryngology-Association for Research in Otolaryngology Research Forum, Anaheim, Calif, Sept 27, 1980.

Reprint requests to the Otological Research Laboratories, 4331 University Hospital Clinic, 456 Clinic Dr, Columbus, OH 43210 (Dr Lim).

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