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Eric Javel, PhD; Daniel F. Mouney, MD; JoAnn McGee; Edward J. Walsh, MS

Arch Otolaryngol. 1982;108(2):71-76.

Abstract
• Auditory brainstem-evoked responses (ABR) to clicks were recorded in unanesthetized restrained cats before, during, and after systemic intravenous infusion of lidocaine hydrochloride. The drug was infused continuously at varying rates. Lidocaine's major effect on ABR was to lengthen latent periods to all waveform peaks in proportion with the infusion rate. The effect on latent periods was cumulative throughout the auditory brainstem, ie, all interpeak time intervals increased. Increases in ABR latencies were not due to reductions in effective stimulus intensity because lidocaine did not reduce ABR component amplitudes or increase thresholds. The effects of the drug were reversible. The data are consistent with the notion that lidocaine, directly or indirectly, works throughout the auditory brainstem to increase axonal and synaptic conduction times.

(Arch Otolaryngol 1982;108:71-76)

Author Affiliations
From The Boys Town Institute for Communication Disorders in Children, Omaha. Dr Mouney is currently with the Department of Otolaryngology, Louisiana State University Medical School, New Orleans.

Footnotes
Accepted for publication July 8, 1981.

Reprint requests to The Boys Town Institute for Communication Disorders in Children, 555 N 30th St, Omaha, NE 68131 (Dr Javel).

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