This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Canine Model

John S. Supance, MD; James S. Reilly, MD; William J. Doyle, PhD; Charles D. Bluestone, MD; Jeffrey Hubbard, MD

Arch Otolaryngol. 1982;108(11):727-731.

Abstract
• We developed a canine animal model of subglottic stenosis following prolonged intubation with modified noncuffed endotracheal tubes. None of the puppies intubated for seven days had an irreversible stenosing subglottic lesion, whereas all animals intubated for 14 days or more had at least a 40% to 50% reduction of the subglottic lumen secondary to maturing fibrotic stenosis. The model described is more congruent with the known and suspected pathogenesis in those infants and children who require prolonged endotracheal intubation and subsequently acquire subglottic stenosis, and can be used in evaluating the efficacy of medical therapy or surgical therapy, or both, in the prevention or management of this disease.

(Arch Otolaryngol 1982;108:727-731)

Author Affiliations
From the Departments of Otolaryngology (Drs Supance, Reilly, Doyle, and Bluestone) and Pathology (Dr Hubbard), University of Pittsburgh School of Medicine, and Children's Hospital of Pittsburgh.

Footnotes
Accepted for publication June 17, 1982.

Read in part before the Association of Research in Otolaryngology, St Petersburg Beach, Fla, Jan 20, 1982.

Reprint requests to the Department of Otolaryngology, Children's Hospital of Pittsburgh, 125 DeSoto St, Pittsburgh, PA 15213 (Dr Supance).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acute and Chronic Changes in the Subglottis Induced by Graded Carbon Dioxide Laser Injury in the Rabbit Airway
Otteson et al.
Arch Otolaryngol Head Neck Surg 2008;134:694-702.
ABSTRACT | FULL TEXT  

Graded Carbon Dioxide Laser-Induced Subglottic Injury in the Rabbit Model
Chafin et al.
Arch Otolaryngol Head Neck Surg 2007;133:358-364.
ABSTRACT | FULL TEXT  

Cartilage Graft Epithelialization A Preliminary Study Using a Goat Model
Wiatrak et al.
Arch Otolaryngol Head Neck Surg 1993;119:777-781.
ABSTRACT