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Pierre Gehanno, MD; Charles Guedon, MD

Arch Otolaryngol. 1981;107(3):145-147.

Abstract
• We describe a new experimental model for the study of caustic stenosis of the esophagus in the rat. Sixty-five Wistar rats were given a standard esophageal lye burn. Animals were divided into two groups: (1) a control group and (2) a treatment group that received penicillamine from the day after the esophageal lye burn. Stenosis developed in only two of the 23 treated rats. Our conclusion is that penicillamine-induced lathyrism inhibits the onset of stenosis in the rat. Double-blind controlled studies of the effect of penicillamine in the prevention of corrosive strictures of the esophagus in man seem warranted.

(Arch Otolaryngol 1981;107:145-147)

Author Affiliations
From the Department of Head and Neck Surgery, Claude-Bernard Hospital, Paris.

Footnotes
Accepted for publication May 14, 1980.

Reprint requests to Department of Head and Neck Surgery, Claude-Bernard Hospital, 10 Ave de la Porte d'Aubervilliers 75019, Paris, France (Dr Gehanno).

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