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Temporal Bone Histopathologic Findings in Down's Syndrome
Takehiko Harada, MD;
Isamu Sando, MD, DMS
Arch Otolaryngol. 1981;107(2):96-103.
Abstract
• We report the results of a histopathologic study of 12 temporal bones from seven patients with Down's syndrome and of a dimensional study of the cochlea and the vestibular apparatuses of most of these specimens. Histopathologic study disclosed numerous abnormalities of the middle ear but only a limited number of inner ear abnormalities. The dimensional study showed that, while in the majority of cases the cochlea was shortened, most of the vestibular measurements were within the normal range. We also discuss hearing loss in patients with Down's syndrome and present our hypothesis that remnants of mesenchymal tissue in the round window niche might cause a certain degree of conductive hearing loss in such cases.
(Arch Otolaryngol 107:96-103, 1981)
Author Affiliations
From the Division of Otopathology, Department of Otolaryngology, Eye and Ear Hospital, University of Pittsburgh School of Medicine. Dr Harada is now with the Department of Otolaryngology, University of Tokyo School of Medicine.
Footnotes
Accepted for publication May 16, 1980.
Reprint requests to Division of Otopathology, Department of Otolaryngology, Eye and Ear Hospital, 230 Lothrop St, Pittsburgh, PA 15213 (Dr Sando).
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