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Mark E. Beaugard, MD; Shinichiro Asakuma, MD; James B. Snow, Jr, MD

Arch Otolaryngol. 1981;107(2):104-109.

Abstract
• Chloramphenicol is not ototoxic if administered for systemic effect, but topical applications of it to the middle ear produce severe cochlear toxic effects. Ethacrynic acid potentiates the ototoxicity of aminoglycosides. Guinea pigs were administered chloramphenicol or kanamycin sulfate with ethacrynic acid to compare the ototoxicity of chloramphenicol and ethacrynic acid with the ototoxicity of kanamycin and ethacrynic acid. Preyer's reflex audiometry and measurement of the endocochlear dc potential, the cochlear microphonics, and the negative potential of the organ of Corti indicate that ethacrynic acid does not potentiate the ototoxicity of chloramphenicol. There is not even indirect evidence that the bloodcochlear barrier for chloramphenicol is altered by ethacrynic acid. Assuming that the ototoxicity of chloramphenicol and ethacrynic acid are similar for man and guinea pig, the combination of the administration of chloramphenicol and ethacrynic acid for systemic effect in dosages commonly used clinically should not produce greater ototoxicity than either agent administered alone.

(Arch Otolaryngol 107:104-109, 1981)

Author Affiliations
From the Department of Otorhinolaryngology and Human Communication, University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Accepted for publication Nov 30, 1979.

Reprint requests to 3400 Spruce St, Philadelphia, PA 19104 (Dr Snow).

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