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Prognostic Factors for Tumor Response

Shan R. Baker, MD; Robert W. Makuch, PhD; Gregory T. Wolf, MD

Arch Otolaryngol. 1981;107(11):683-689.

Abstract
• A multi-institutional National Cancer Institute trial of preoperative cisplatin (100 mg/sq m, day 1) and intravenous bleomycin sulfate (15-mg/sq m bolus, day 3, followed by 15 mg/sq m/day, 24-hour infusion, days 3 to 7) was carried out in patients with previously untreated, resectable stage III and IV squamous cell carcinoma of the oral cavity or larynx and hypopharynx. Of the first 113 patients who received a single course of induction chemotherapy, eight complete responses and 47 partial responses at the primary site were observed (49%). Of 76 patients who had clinically positive regional adenopathy, 11 complete responses and 31 partial responses of neck nodes were observed (55%). The response rates of the primary tumor and the regional nodes to induction chemotherapy were assessed with respect to several pretreatment patient and tumor characteristics and to reported toxic effects after chemotherapy. Of the factors examined, no prognostic indicators were highly useful to predict the response of the primary tumor. However, the response of regional adenopathy was associated with the initial N class, the site of primary tumor, and the response of the primary tumor to induction chemotherapy.

(Arch Otolaryngol 1981;107:683-689)

Author Affiliations
From the Department of Otorhinolaryngology, University of Michigan, Ann Arbor (Drs Baker and Wolf), and the Biometric Research Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Md (Dr Makuch).

Footnotes
Accepted for publication May 7, 1981.

Read before the combined meeting of the Society of Head and Neck Surgeons and the American Society for Head and Neck Surgery, Phoenix, Ariz, March, 1981.

Reprint requests to 1405 E Ann St, Ann Arbor, MI 48109 (Dr Baker).

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