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Shizuo Komune, MD; James B. Snow, Jr, MD

Arch Otolaryngol. 1981;107(10):594-597.

Abstract
• Seven milligrams per kilogram of body weight of cisplatin and 50 mg/kg of body weight of ethacrynic acid were given intravenously to guinea pigs. The threshold for Preyer's reflex, the cochlear microphonics (CM), and the endocochlear dc potential (EP) were measured during a four-day period after the injection. The changes in Preyer's reflex audiometry and the CM were more severe than that of the EP. These changes are greater than those that occur with the administration of each agent independently. The ototoxic interaction seemingly has a greater effect on the hair cells than on the stria vascularis. Baseline and periodic audiometry should be performed when both of these drugs are administered clinically.

(Arch Otolaryngol 1981;107:594-597)

Author Affiliations
From the Department of Otorhinolaryngology and Human Communication, University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Accepted for publication May 15, 1980.

Read in part before the Scientific Forum of the American College of Surgeons, Atlanta, Oct 21, 1980.

Reprint requests to the Department of Otorhinolaryngology and Human Communication, University of Pennsylvania School of Medicine, 3400 Spruce, Philadelphia, PA 19104 (Dr Snow).

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