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James R. Chandler, MD; Francisco J. Tejada, MD

Arch Otolaryngol. 1981;107(1):27-29.

Abstract
• Eighty-two patients with advanced cancer of the head and neck have been treated with sequential administration of methotrexate and cisplatin. Methotrexate was given orally (50 mg/sq m). Cisplatin was given intravenously 24 hours later. Treatment was repeated four times at weekly intervals. This method of administration is based on laboratory evidence, including cell kinetic studies. Forty-three patients were operated on. Those with involved or close surgical margins or with more than one cancerous neck node were also treated with therapeutic postoperative radiation therapy. Twenty-one patients were treated with only radiation therapy. After surgery and/or radiation therapy, patients were randomly selected as to who would receive further chemotherapy or who would be under observation only. Twenty-two patients are still in the early phases of treatment and followup, so their conditions could not be evaluated. Early results indicate a 64% response to initial chemotherapy and no increase in operative difficulty, morbidity, or mortality.

(Arch Otolaryngol 107:27-29, 1981)

Author Affiliations
From the Departments of Otolaryngology (Dr Chandler) and Oncology (Dr Tejada), University of Miami School of Medicine.

Footnotes
Accepted for publication Sept 16, 1980.

Reprint requests to Department of Otolaryngology (D-48), University of Miami School of Medicine, PO Box 016960, Miami, FL 33101 (Dr Chandler).

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