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Vestibular Nerve in Meniere's Disease
Jukka Ylikoski, MD;
Yrjö Collan, MD;
Tauno Palva, MD
Arch Otolaryngol. 1980;106(8):477-483.
Abstract
• Biopsy specimens of vestibular nerves of 40 patients with severe Meniere's disease were studied by microscopy. In 17 patients, a translabyrinthine eighth nerve transection was done; in 23 patients, a middle fossa vestibular neurectomy was done. Many of the nerve fibers had thickened and deformed myelin coats; some were thinly myelinated fibers and some showed degraded myelin. No macrophages were present. Occasional vestibular ganglion cells had thin myelin coats. In six patients, there were lighter areas between the fibers. In these there were roughly parallel astrocyte processes, with numerous cytoplasmic filaments. The light areas were surrounded by a basement membrane. Four of these patients showed continuation of vertiginous symptoms after operation and were not helped by surgery. These patients may suffer from a neuropathy that is different from the more common causes of Meniere's disease.
(Arch Otolaryngol 106:477-483, 1980)
Author Affiliations
From the Department of Otolaryngology (Drs Ylikoski and Palva), and the Sections of Histology (Dr Collan) and Electron Microscopy (Drs Ylikoski and Collan), Department of Pathology, University of Helsinki.
Footnotes
Accepted for publication Sept 4, 1979.
Reprint requests to Department of Otolaryngology, University of Helsinki, Haartmaninkatu 4E, 00290 Helsinki 29, Finland (Dr Palva).
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