This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Role of Lymphocyte Response and Clinical Stage

Vernon K. Jenkins, PhD; Ceri M. Griffiths, MD; Pranab Ray, MD; Robert R. Perry, PhD; Marvin H. Olson, MD

Arch Otolaryngol. 1980;106(7):414-418.

Abstract
• The mean number of lymphocytes, response to phytohemagglutinin (PHA), and response to concanavalin A (Con A) in whole-blood cultures for 106 patients with head and neck cancer were 83%, 73%, and 64%, respectively, of values for healthy control individuals. During radiotherapy, lymphocyte counts declined to 44% and PHA and Con A responses declined to about one third of control values. Lymphocyte counts slowly increased after treatment to 77% of control values after two years, but responses to mitogens remained at about 40%. Responses to PHA and Con A for 38 patients who lived beyond 18 months were significantly greater before and after treatment than responses for 39 patients who died within 18 months. In general, a poor pretreatment response to PHA and Con A correlated with a poor clinical course, whereas responses near the control level indicated a good clinical course.

(Arch Otolaryngol 106:414-418, 1980)

Author Affiliations
From the Departments of Radiology (Drs Jenkins, Ray, Perry, and Olson) and Otolaryngology (Dr Griffiths), University of Texas Medical Branch, Galveston.

Footnotes
Accepted for publication July 5, 1979.

Reprint requests to Department of Radiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77550 (Dr Jenkins).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Report of a Clinical Trial in 12 Patients With Head and Neck Cancer Treated Intratumorally and Peritumorally With Multikine
Feinmesser et al.
Arch Otolaryngol Head Neck Surg 2003;129:874-881.
ABSTRACT | FULL TEXT  

Interleukins and Contrasuppression Induce Immune Regression of Head and Neck Cancer
Hadden et al.
Arch Otolaryngol Head Neck Surg 1994;120:395-403.
ABSTRACT  

Lymphokine Production and Lymphocyte Subpopulations in Patients With Head and Neck Squamous Carcinoma
Wolf et al.
Arch Otolaryngol Head Neck Surg 1984;110:731-735.
ABSTRACT