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I. Kaufman Arenberg, MD; Theodore L. Goodfriend, MD

Arch Otolaryngol. 1980;106(7):383-386.

Abstract
• The acute audiologic effects of glycerin and furosemide were measured with and without indomethacin pretreatment in two patients. The positive effects of glycerin were not blocked by indomethacin. The positive effect of furosemide on discrimination score was blocked by indomethacin. The concomitant rise in plasma renin level after furosemide was also blocked by indomethacin. A role for prostaglandins in inner ear fluid dynamics is suggested by this study. It appears that glycerin and furosemide affect inner ear fluid dynamics by different mechanisms.

(Arch Otolaryngol 106:383-386, 1980)

Author Affiliations
From the William S. Middleton Veterans Medical Center, Madison, Wis; and the Departments of Surgery (Otolaryngology) (Dr Arenberg), Internal Medicine, and Pharmacology (Dr Goodfriend) University of Wisconsin Hospitals and Center for Health Sciences, Madison.

Footnotes
Accepted for publication Jan 24, 1979.

Reprint requests to Department of Surgery (Otolaryngology), University of Wisconsin Hospitals and Center for Health Sciences, 600 Highland Ave, Madison, WI 53792 (Dr Arenberg).

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