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Effect of Fluoride on -Chymotrypsin

Santosh K. Kacker, MD; George E. Shambaugh, Jr, MD

Arch Otolaryngol. 1980;106(5):260-261.

Abstract
• Sodium fluoride has been demonstrated by spectrophotometric experiment to have an inhibitory effect on the hydrolyzing action of -chymotrypsin. Sodium fluoride in moderate therapeutic dosage possibly can retard or completely inhibit the activity of bone-resorbing enzymes in the otospongiotic focus, thus retarding or arresting active expansion of a focus and resulting in stabilizing or arresting the progression of sensorineural hearing loss that is associated with otospongiosis.

(Arch Otolaryngol 106:260-261, 1980)

Author Affiliations
From the Department of Otolaryngology, All-India Institute of Medical Sciences, Ansari Nagar C 11-10, New Delhi 16, India (Dr Kacker), and Northwestern University Medical School, Chicago (Dr Shambaugh).

Footnotes
Accepted for publication Oct 26, 1978.

Reprint requests to 40 S Clay St, Hinsdale, IL 60521 (Dr Shambaugh).

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