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Replacement of Tumor-Involved Mandible by Cryosurgically Devitalized AutograftHuman Experience
Charles W. Cummings, MD;
Bruce Leipzig, MD
Arch Otolaryngol. 1980;106(5):252-254.
Abstract
• In management of a malignant floorof-mouth tumor invading the mandible, the mandible is the main focus of reconstruction and the most likely site of rehabilitative failure. Creation of a functional and cosmetically appealing replacement is a major therapeutic goal. In canines, neoosteogenesis does occur in mandibular autografts exposed to two consecutive freeze-thaw cycles prior to reimplantation. Also postoperative radiotherapy in canines does not elicit a higher incidence of complications or promote failure of the mandibular autograft to reconstitute itself. This technique was used in a 52-year-old man with a large lesion in the anterior floor of the mouth extending into the inner cortex of the mandible. The theoretical advantages of nonantigenicity and excellence of mandibular configuration are obvious. That there are important pitfalls that may lead to reconstructive failure is equally obvious.
(Arch Otolaryngol 106:252-254, 1980)
Author Affiliations
From the Departments of Otolaryngology, University of Washington, Seattle (Dr Cummings), and the University of Texas Medical Branch, Galveston (Dr Leipzig).
Footnotes
Accepted for publication Sept 12, 1979.
Read before the annual meeting of the American Society for Head and Neck Surgery, Los Angeles, April 5, 1979.
Reprint requests to Department of Otolaryngology, RL-30, University of Washington, Seattle, WA 98195 (Dr Cummings).
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