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A Double-blind Clinical Study

William R. Wilson, MD; Frederick M. Byl, MD; Nan Laird, PhD

Arch Otolaryngol. 1980;106(12):772-776.

Abstract
• Double-blind studies were conducted for the treatment of idiopathic sudden hearing loss (ISHL) with oral steroids. The condition was defined as not less than a 30-dB loss over three contiguous frequencies in three days or less. Follow-up audiograms were obtained four weeks and three months later. Specific audiologic guidelines for the assessment of hearing recovery were used to ensure objectivity. Steroids had a statistically significant effect on the recovery of hearing in patients with moderate hearing losses. The nature of the hearing loss and its susceptibility to improvement with steroid therapy lend support to the hypothesis that viral cochlitis is the primary cause of ISHL.

(Arch Otolaryngol 106:772-776, 1980)

Author Affiliations
From the Department of Surgery, Massachusetts Eye and Ear Infirmary, and the Department of Otolaryngology, Harvard Medical School, Boston (Dr Wilson); the Otolaryngology Department, Kaiser-Permanente Medical Group, Oakland, Calif (Dr Byl); and the Department of Biostatistics, Harvard School of Public Health, Boston (Dr Laird).

Footnotes
Accepted for publication March 3, 1980.

Read before the midwinter research meeting of the Association for Research in Otolaryngology, St Petersburg, Fla, Jan 23, 1980.

Reprint requests to Department of Surgery, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (Dr Wilson).

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