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Henning Heumann, MD; Eberhard Steinbach, MD

Arch Otolaryngol. 1980;106(12):734-736.

Abstract
• This study investigated the effects of enbucrilate (Histoacryl) on the middle ear. Small amounts of the adhesive were used in 81 middle-ear operations performed on 50 rabbits. Light microscopic investigation of these ears 1, 2, and 3 months after surgery showed bone necrosis and a granulation tissue reaction surrounded by foreign-body giant cells. Inner-ear changes were observed in a third of the cases. Therefore, enbucrilate should only be used with extreme care and in minute quantities and never near the labyrinthine capsule.

(Arch Otolaryngol 106:734-736, 1980)

Author Affiliations
From the Department of Otolaryngology, University Hospital Tübingen, Federal Republic of Germany.

Footnotes
Accepted for publication April 12, 1980.

Reprint requests to Department of Otolaryngology, University of Tübingen, Silcherstr 5, 7400 Tübingen, Federal Republic of Germany (Dr Heumann).

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