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Kaye E. Fox, PhD; Robert E. Brummett, PhD; Richard Brown

Arch Otolaryngol. 1980;106(1):44-49.

Abstract
• Dose-response experiments comparing the ototoxic liability of the aminoglycoside antibiotics gentamicin sulfate and gentamicin C₁ sulfate were conducted on guinea pigs. Measures of cochlear electrophysiology, histology, and the pharmacokinetic disposition of the drugs in the plasma and perilymph were made. Electrophysiological and histological measures indicated that gentamicin is more ototoxic than is gentamicin C₁.

(Arch Otolaryngol 106:44-49, 1980)

Author Affiliations
Donna Himes

From the Kresge Hearing Research Laboratory, University of Oregon Health Sciences Center, Portland.

Footnotes
Accepted for publication Nov 16, 1978.

Reprint requests to Kresge Hearing Research Laboratory, University of Oregon Health Sciences Center, 3181 SW Sam Jackson Park Rd, Portland, OR 97201 (Dr Brummett).

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