This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A New Adjunct in the Management of Radiation Necrosis

Jefferson C. Davis, MD; Jared M. Dunn, MD; George A. Gates, MD; Richard D. Heimbach, MD

Arch Otolaryngol. 1979;105(2):58-61.

Abstract
• Radiation necrosis is a significant complication of surgery for previously irradiated head and neck malignant neoplasms. We used hyperbaric oxygen therapy (HBO) as adjunctive therapy in 52 cases of radiation necrosis. Thirty-nine cases involved the head and neck. Nineteen of 23 cases of osteoradionecrosis of the mandible remain arrested after as much as two years of follow-up. Fifteen of the 16 cases of soft-tissue radionecrosis of the head and neck were successfully managed with HBO therapy as an adjunct to surgery and antibiotics. Fibroblastic proliferation, collagen formation, and capillary budding require at least 20 to 30 mm Hg of wound Po<L>₂</L>. This effect can be achieved in wounds that are rendered hypoxic by radiation endarteritis and ischemia with high-dose or hyperbaric oxygenation.

(Arch Otolaryngol 105:58-61, 1979)

Author Affiliations
From the Hyperbaric Medicine Division, US Air Force School of Aerospace Medicine, Brooks AFB, Tex (Drs Davis, Dunn, and Heimbach), and the Department of Otorhinolaryngology, University of Texas, San Antonio (Dr Gates).

Footnotes
Accepted for publication Nov 24, 1977.

Read before the 19th annual meeting of the American Society of Head and Neck Surgery, Boston, May 11-12, 1977.

The opinions contained herein are the private ones of the authors, and are not to be construed as official or reflecting the views of the US Air Force or University of Texas.

Reprint requests to 8710 Data Point, 7604, San Antonio, TX 78229 (Dr Davis).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hyperbaric Oxygen Therapy
Grim et al.
JAMA 1990;263:2216-2220.
ABSTRACT  

Treatment of the Patient With Extensive Osteoradionecrosis of the Mandible
Dolezal et al.
Arch Otolaryngol Head Neck Surg 1982;108:179-183.
ABSTRACT