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An Immunoperoxidase Study

Majid Ali, MD; A. Olusegun Fayemi, MD; Donald J. Nalebuff, MD

Arch Otolaryngol. 1979;105(12):695-697.

Abstract
• An immunoperoxidase technique was applied to the localization of IgE in formaldehyde-solution-fixed, paraffin-embedded tissue. The content and distribution of IgE in tonsil and adenoid tissues from ten patients with histories of inhalant allergies and elevated serum levels of total and allergen-specific IgE were investigated. Compared with tissues from five nonatopic subjects, the tissues from atopic individuals were observed to harbor a much larger population of IgE-forming plasma cells. The profusion of IgE plasma cells in nasopharyngeal lymphoid tissue, observed in this study, furnishes strong anatomic evidence for a pathogenetic role of IgE in inhalant allergies. For cellular and tissue localization of IgE, the immunoperoxidase technique offers clear advantages over previously used immunofluorescence procedures.

(Arch Otolaryngol 105:695-697, 1979)

Author Affiliations
From the Department of Immunology, Holy Name Hospital, Teaneck, NJ.

Footnotes
Accepted for publication Nov 30, 1978.

Reprint requests to Department of Immunology, Holy Name Hospital, Teaneck, NJ 07666 (Dr Ali).

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