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Immunological Findings in a Rare Case Treated With BCG Vaccine, Autologous Tumor Cells, and Cytarabine

Staffan Edström, MD; Stellan Jacobsson, MD; Pål-Henry Jeppsson, MD

Arch Otolaryngol. 1979;105(1):48-50.

Abstract
• A case of mucosal melanoma involved the bronchus, maxillary sinus, and small intestine. Treatment with a combination of autologous tumor cells, BCG vaccine, and cytarabine was given, and the immunological system was investigated regularly. After each treatment episode, there was a transient improvement of the cell-mediated immunity to melanoma antigens. The cutaneous delayed hypersensitivity reaction to PPD was converted to a permanently positive one. In the final stage of the disease, the number of T cells was decreased. Difficulty occurred in interpreting the immunological findings according to the clinical condition.

(Arch Otolaryngol 105:48-50, 1979)

Author Affiliations
From the Department of Otolaryngology, Sahlgren's Hospital, University of Göteborg, Sweden.

Footnotes
Accepted for publication Nov 24, 1977.

Reprint requests to Department of Otolaryngology, Sahlgren's Hospital, University of Göteborg, S-413 45 Göteborg, Sweden (Dr Edström).

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