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Ear, Nose, and Throat Manifestations

Elliott Foucar, MD; Juan Rosai, MD; Ronald F. Dorfman, MRCPath

Arch Otolaryngol. 1978;104(12):687-693.

Abstract
• Sinus histiocytosis with massive lymphadenopathy (SHML) is a newly recognized, distinct, pseudolymphomatous benign entity with very characteristic microscopic features. Most patients are children or young adults with massive painless cervical adenopathy, although other node groups and extranodal sites often are involved.

Sixteen patients with SHML involving the upper respiratory tract and/or salivary gland are presented. Nine of the patients had ear, nose, and throat (ENT) manifestations at the time of presentation. In most cases the ENT involvement resulted in prominent clinical symptoms. Treatment included surgery, antibiotics, irradiation, chemotherapy, and steroids, frequently in combination, but no consistent pattern of response emerged from the study. These 16 patients were very similar clinically to patients with SHML who did not have ENT disease, indicating that extranodal involvement is not associated with more aggressive disease.

(Arch Otolaryngol 104:687-693, 1978)

Author Affiliations
From the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis (Drs Foucar and Rosai), and Department of Pathology, Stanford (Calif) University School of Medicine (Dr Dorfman).

Footnotes
Accepted for publication March 9, 1978.

Reprint requests to Department of Laboratory Medicine and Pathology, Box 609, Mayo Memorial Bldg, 420 Delaware St SE, Minneapolis, MN 55455 (Dr Rosai).

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