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Prognosis of Nasopharyngeal Carcinoma by Epstein-Barr Virus Antibody Titer
Tsong-chou Lynn, MD;
Mow-ming Hsu, MD;
Ti Hsieh, MD;
Shih-mien Tu, MD
Arch Otolaryngol. 1977;103(3):128-132.
Abstract
• A total of 433 samples of serum were collected from 305 patients with histopathologically proved anaplastic nasopharyngeal carcinoma (NPC). Antibodies against viral capsid antigens (VCA) of Epstein-Barr (EB) virus were titrated by means of indirect fluorescent antibody technique, using P3HR-1 cells as the target. High anti-VCA antibody titer in patients with NPC was found beginning to decline at the end of radiotherapy. Most (66.7%) of the patients were found to have a detectable reduction in antibody titer within six months after radiotherapy. Persistent high antibody titer after treatment correlates to high risk of the recurrence of the disease. This prognostic importance of anti-VCA titer becomes apparent at the end of radiotherapy, significant (P <.05) within one year after treatment, and highly significant (P <.0005) over one year after treatment.
(Arch Otolaryngol 103:128-132, 1977)
Author Affiliations
From the Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.
Footnotes
Accepted for publication Sept 15, 1976.
Read before the Tenth Annual Duke-McPherson Otolaryngology Symposium, Durham, NC, May 22, 1976.
Reprint requests to Department of Otolaryngology, National Taiwan University Hospital, 1 Chang-te St, Taipei, Taiwan 100, Republic of China (Dr Lynn).
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