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Inner Ear Degeneration in Reye's Syndrome
Raúl Hinojosa, MD;
John R. Lindsay, MD
Arch Otolaryngol. 1977;103(11):634-640.
Abstract
• A 9-year-old girl developed Reye's syndrome. On admission to the hospital on the fourth day of illness, responses for verbal stimuli had been absent, but were present for painful stimuli. Coma developed on the fourth day and was present until death ten days later. The fundus of both internal meatus showed vascular congestion of nerves with evidence of repeated hemorrhages. All structures within the endolymphatic system showed advanced degeneration, with exception of the tectorial membrane and cupulae. One ear showed vascular congestion, formation of thrombi, and free hemorrhage within the modiolus and spiral ganglion. In the other ear, congested vessels in nerves in the meatus were obstructed by swelling at the cribriform area. The degenerative changes corresponded closely to those produced experimentally in guinea pigs by interruption of arterial circulation to the inner ear.
(Arch Otolaryngol 103:634-640, 1977)
Author Affiliations
From the Department of Otolaryngology, Pritzker School of Medicine, University of Chicago.
Footnotes
Accepted for publication March 28, 1977.
Reprint requests to Department of Otolaryngology, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Hinojosa).
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