 |
|
Studies in Permeability of the Middle Ear MucosaThe Feasibility of Blocking Inflammatory Mediators
Robert P. Frady, MD;
Wiley A. Parker, MD;
Richard T. Jackson, PhD
Arch Otolaryngol. 1977;103(1):47-51.
Abstract
• The permeability and vasodilation of the middle ear mucosa was measured in dogs that were treated topically with histamine, bradykinin, prostaglandins, and bacterial endotoxin. All of these inflammatory mediators increased permeability and caused vasodilation. The antihistamine diphenhydramine hydrochloride, when given topically or intravenously, prevented the increase in permeability caused by histamine but had little or no effect on vasodilation. The antihistamine also reduced the permeability response to bradykinin.
As antihistamines are not always useful in treating otitis media, other inflammatory mediators found in human effusions may be responsible for the condition. Because of our relative ignorance of the inflammatory process in otitis media, control of the process by drug treatment is not hopeful at present.
(Arch Otolaryngol 103:47-51, 1977)
Author Affiliations
From the Division of Otolaryngology, Emory University School of Medicine, Atlanta.
Footnotes
Accepted for publication Sept 14, 1976.
Reprint requests to Division of Otolaryngology, Emory University School of Medicine, 441 Woodruff Bldg, Atlanta, GA 30322 (Dr Jackson).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Importance of Respiratory Viruses in Acute Otitis Media
Heikkinen and Chonmaitree
Clin. Microbiol. Rev. 2003;16:230-241.
ABSTRACT
| FULL TEXT
Effect of Inflammatory Mediators on Nasal Mucosa
Jackson and Burson
Arch Otolaryngol Head Neck Surg 1977;103:441-444.
ABSTRACT
|
