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Osmolality Changes in Perilymph After Systemic Administration of Glycerin
S. K. Juhn, MD;
Sergio Prado, MD;
Jeffrey Pearce
Arch Otolaryngol. 1976;102(11):683-685.
Abstract
• Blood osmolality was altered in guinea pigs by intravenous administration of glycerin (glycerol). After glycerin administration, serum osmolality increased rapidly, reaching a plateau within 15 minutes. Perilymph osmolality lagged significantly behind the increase of serum osmolality and equalled serum osmolality only after one hour. While perilymph osmolality responded to changes of serum osmolality, there was some time lag noted in the response of perilymph, suggesting the existence of a blood-labyrinth barrier. It was observed that this barrier is permeable to glycerin and water, suggesting the possibility of transient reduction of hydrostatic pressure in the labyrinth by the injection of an osmotic agent into the systemic circulation.
(Arch Otolaryngol 102:683-685, 1976)
Author Affiliations
From the Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.
Footnotes
Accepted for publication June 22, 1976.
Read before the Committee for Research in Otolaryngology, American Academy of Ophthalmology and Otolaryngology, and the Association for Research in Otolaryngology, Dallas, Sept 20, 1975.
Reprint requests to Department of Otolaryngology, Medical Research East, 2630 University Ave SE, Minneapolis, MN 55414 (Dr Juhn).
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