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A Review of Modern Concepts

Randall G. Michel, MD; William R. Hudson, MD; Thaddeus H. Pope, MD

Arch Otolaryngol. 1975;101(9):544-547.

Abstract
• We review the subject of angioneurotic edema with special emphasis on the more clearly defined entity of hereditary angioneurotic edema. The clinical presentations of the various forms of angioneurotic edema are discussed. Attention is directed toward the attempts that have been made to define this group of diseases in terms of their underlying biochemical mechanisms. A simplified schema of the serum complement system is presented. We conclude that only after we understand such biochemical interactions will we be able to effect a more definitive form of therapy for the angioneurotic edemas.

(Arch Otolaryngol 101:544-547, 1975)

Author Affiliations
From the Department of Surgery, Division of Otolaryngology, Duke University Medical Center (Drs. Michel and Hudson), and McPherson Hospital (Dr. Pope), Durham, NC.

Footnotes
Accepted for publication March 29, 1975.

Reprint requests to the Division of Otolaryngology, Duke University Medical Center, Durham, NC 27710 (Dr. Michel).

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