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Signal Transmission in the Cochlear Hair Cell-Nerve Junction

Juergen Tonndorf, MD

Arch Otolaryngol. 1975;101(9):528-535.

Abstract
• In 1961, Hallowell Davis proposed the occurrence of the following general sequence of interrelated events in sense organs, in response to specific sensory inputs: (1) the generation of receptor potentials in the sensory cells; (2) chemical transmission across the synapses between hair cells and afferent dendrites; and (3) the triggering of postsynaptic generator potentials capable of eliciting the actual nerve action potentials. Although at the time of his writing there was no evidence for this hypothesis in the auditory organ, there is now good support for the occurrence of all three events and for their general importance in the sensory transduction process.

(Arch Otolaryngol 101:528-535, 1975)

Author Affiliations
From the Department of Otolaryngology, Fowler Memorial Laboratory, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Accepted for publication Feb 6, 1975.

Reprint requests to College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032 (Dr. Tonndorf).

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