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Immunochemical and Bacteriological Investigations

Yea S. Liu, MS; David J. Lim, MD; Raymond W. Lang, PhD; Herbert G. Birck, MD

Arch Otolaryngol. 1975;101(5):278-286.

Abstract
Middle ear effusions from 100 patients (ages 6 months to 10 years) with serous otitis media were examined. The IgA, IgG, and lysozyme were demonstrated at a higher level in the effusions than the corresponding sera, indicating local production. The mucoid type contained higher level of immunoglobulins and lysozyme compared to serous type effusions.

Bacteria were found in 77% of the effusions by means of a smear, and 52% yielded positive bacterial culture. The incidence of positive culture in effusions of the patients less than 6 years of age was 60%, while the group older than 6 years old was 32%, and the group over 8 was only 22%. Bacterial recovery rate was inversely related to the dramatic increase with age of IgA and IgG and Iysozyme levels in effusions.

Author Affiliations
From the Otological Research Laboratories, Department of Otolaryngology (Drs. Liu and Lim), Department of Medical Microbiology (Dr. Lang), Ohio State University College of Medicine; and the Children's Hospital (Dr. Birck), Columbus.

Footnotes
Accepted for publication Dec 5, 1974.

Read in part before the Research Committee meeting of the American Academy of Ophthalmology and Otolaryngology, Dallas, Oct 5,1974.

Reprint requests to the Otological Research Laboratories, Ohio State University Hospitals, 3331 University Hospital Clinics, 465 Clinic Dr, Columbus, OH 43210 (Dr. Lim).

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