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Cochlear and Vestibular Gentamicin ToxicityA Clinical Study of Systemic and Topical Usage
Vijay S. Dayal, MB, MSc, FRCS(C);
Edson L. Smith, MD;
W. Greg McCain, MD
Arch Otolaryngol. 1974;100(5):338-340.
Abstract
Vestibular and cochlear toxicity from gentamicin occurred in patients with chronic renal failure and severe thermal burns. In the former group, the toxicity was primarily vestibular. In a small number of these patients, maintenance of balance was severely compromised due to a concomitant loss of proprioception secondary to polyneuropathy seen sometimes in chronic renal failure. In the burn group of patients, the vestibular toxicity was accompanied by moderate to severe hearing losses. The use of topical gentamicin may account for this additional change in this group.
Author Affiliations
From the Department of Otolaryngology (Dr. Dayal) and the Division of Plastic Surgery (Dr. McCain), University of Toronto and Toronto General Hospital (Dr. Smith).
Footnotes
Accepted for publication Feb 13, 1974.
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