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John A. McCurdy, Jr., MD; James G. McCormick, PhD; James A. Harrill, MD

Arch Otolaryngol. 1974;100(2):143-147.

Abstract
The effect of renal failure on the ototoxicity of ethacrynic acid was shown in the guinea pig by the intravenous administration of this substance (20 mg/kg) following bilateral nephrectomy. Cochlear activity was measured by determining the sensitivity function of the alternating current cochlear potential (1µv isopotential curve) at 17 different frequencies ranging from 100 to 40,000 Hz. The same dose of ethacrynic acid was shown to have little or no effect on the sensitivity function in normal guinea pigs. The sensitivity functions of animals with bilateral nephrectomy not treated with ethacrynic acid remained stable over a time period identical with the test period for the animals given ethacrynic acid.

Author Affiliations
Winston-Salem, NC

From the Section of Otolaryngology, Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC. Dr. McCurdy is now with the Otolaryngology Service, Madigan Army Medical Center, Tacoma, Wash.

Footnotes
Accepted for publication Dec 10, 1973.

Reprint requests to Section of Otolaryngology, Department of Surgery, Bowman Gray School of Medicine, Winston-Salem, NC 27103 (Dr. McCormick).

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